Role of Serotonergic 1A Receptor Dysfunction in Depression Associated with Parkinson's Disease
Identifieur interne : 000113 ( France/Analysis ); précédent : 000112; suivant : 000114Role of Serotonergic 1A Receptor Dysfunction in Depression Associated with Parkinson's Disease
Auteurs : Benedicte Ballanger [France] ; Helene Klinger [France] ; Julien Eche [France] ; Jerome Lerond [France] ; Anne-Evelyne Vallet [France] ; Didier Le Bars [France] ; Leon Tremblay [France] ; Véronique Sgambato-Faure [France] ; Emmanuel Broussolle [France] ; Stéphane Thobois [France]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Depression is frequent in Parkinson's disease, but its pathophysiology remains unclear. Two recent studies have investigated the role of serotonergic system at the presynaptic level. The objective of the present study was to use positron emission tomography and [18F]MPPF to investigate the role of postsynaptic serotonergic system dysfunction in the pathophysiology of depression in Parkinson's disease. Four parkinsonian patients with depression and 8 parkinsonian patients without depression were enrolled. Each patient underwent a scan using [18F]MPPF, a selective serotonin 1A receptor antagonist. Voxel-by-voxel statistical comparison of [18F]MPPF uptake of the 2 groups of parkinsonian patients and with 7 matched normal subjects was made using statistical parametric mapping (P uncorrected < .001). Compared with nondepressed parkinsonian patients, depressed patients exhibited reduced tracer uptake in the left hippocampus, the right insula, the left superior temporal cortex, and the orbitofrontal cortex. Compared with controls, nondepressed parkinsonian patients presented reduced [18F]MPPF uptake bilaterally in the inferior frontal cortex as well as in the right ventral striatum and insula. Compared with controls, [18F]MPPF uptake was decreased in depressed parkinsonian patients in the left dorsal anterior cingulate and orbitofrontal cortices, in the right hippocampic region, and in the temporal cortex. The present imaging study suggests that abnormalities in serotonin 1A receptor neurotransmission in the limbic system may be involved in the neural mechanisms underlying depression in patients with Parkinson's disease.
Affiliations:
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type="wicri:Area/France/Extraction">000113</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Role of Serotonergic 1A Receptor Dysfunction in Depression Associated with Parkinson's Disease</title><author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 5229, Centre de Neurosciences Cognitives</s1><s2>Bron</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Centre de Neurosciences Cognitives</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Klinger, Helene" sort="Klinger, Helene" uniqKey="Klinger H" first="Helene" last="Klinger">Helene Klinger</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hospices Civils de Lyon, Hôpital Neurologique, Neurologie C and Université Lyon I, Faculté de Médecine et de Maïeutique Lyon Sud Charles Mérieux</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Eche, Julien" sort="Eche, Julien" uniqKey="Eche J" first="Julien" last="Eche">Julien Eche</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hospices Civils de Lyon, Hôpital Neurologique, Service de Psychiatrie de Liaison</s1><s2>Lyon</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Lerond, Jerome" sort="Lerond, Jerome" uniqKey="Lerond J" first="Jerome" last="Lerond">Jerome Lerond</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Hospices Civils de Lyon, Hôpital Neurologique, Service de Psychiatrie de Liaison</s1><s2>Lyon</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Vallet, Anne Evelyne" sort="Vallet, Anne Evelyne" uniqKey="Vallet A" first="Anne-Evelyne" last="Vallet">Anne-Evelyne Vallet</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hospices Civils de Lyon, Hôpital Neurologique, Neurologie C and Université Lyon I, Faculté de Médecine et de Maïeutique Lyon Sud Charles Mérieux</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Le Bars, Didier" sort="Le Bars, Didier" uniqKey="Le Bars D" first="Didier" last="Le Bars">Didier Le Bars</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>CERMEP, 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wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 5229, Centre de Neurosciences Cognitives</s1><s2>Bron</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Centre de Neurosciences Cognitives</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 5229, Centre de Neurosciences Cognitives</s1><s2>Bron</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Centre de Neurosciences Cognitives</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hospices Civils de Lyon, Hôpital Neurologique, Neurologie C and Université Lyon I, Faculté de Médecine et de Maïeutique Lyon Sud Charles Mérieux</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>CNRS, UMR 5229, Centre de Neurosciences Cognitives</s1><s2>Bron</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Centre de Neurosciences Cognitives</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hospices Civils de Lyon, Hôpital Neurologique, Neurologie C and Université Lyon I, Faculté de Médecine et de Maïeutique Lyon Sud Charles Mérieux</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Lyon</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Depression</term><term>Dysfunction</term><term>Emission tomography</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Positron emission tomography</term><term>Serotonin</term><term>Serotonine receptor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etat dépressif</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Récepteur sérotoninergique</term><term>Trouble fonctionnel</term><term>Sérotonine</term><term>Tomoscintigraphie</term><term>Tomographie par émission de positons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depression is frequent in Parkinson's disease, but its pathophysiology remains unclear. Two recent studies have investigated the role of serotonergic system at the presynaptic level. The objective of the present study was to use positron emission tomography and [<sup>18</sup>F]MPPF to investigate the role of postsynaptic serotonergic system dysfunction in the pathophysiology of depression in Parkinson's disease. Four parkinsonian patients with depression and 8 parkinsonian patients without depression were enrolled. Each patient underwent a scan using [<sup>18</sup>F]MPPF, a selective serotonin 1A receptor antagonist. Voxel-by-voxel statistical comparison of [<sup>18</sup>F]MPPF uptake of the 2 groups of parkinsonian patients and with 7 matched normal subjects was made using statistical parametric mapping (P uncorrected < .001). Compared with nondepressed parkinsonian patients, depressed patients exhibited reduced tracer uptake in the left hippocampus, the right insula, the left superior temporal cortex, and the orbitofrontal cortex. Compared with controls, nondepressed parkinsonian patients presented reduced [<sup>18</sup>F]MPPF uptake bilaterally in the inferior frontal cortex as well as in the right ventral striatum and insula. Compared with controls, [<sup>18</sup>F]MPPF uptake was decreased in depressed parkinsonian patients in the left dorsal anterior cingulate and orbitofrontal cortices, in the right hippocampic region, and in the temporal cortex. The present imaging study suggests that abnormalities in serotonin 1A receptor neurotransmission in the limbic system may be involved in the neural mechanisms underlying depression in patients with Parkinson's disease.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Lyon</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Benedicte" last="Ballanger">Benedicte Ballanger</name></noRegion><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name><name sortKey="Eche, Julien" sort="Eche, Julien" uniqKey="Eche J" first="Julien" last="Eche">Julien Eche</name><name sortKey="Klinger, Helene" sort="Klinger, Helene" uniqKey="Klinger H" first="Helene" last="Klinger">Helene Klinger</name><name sortKey="Le Bars, Didier" sort="Le Bars, Didier" uniqKey="Le Bars D" first="Didier" last="Le Bars">Didier Le Bars</name><name sortKey="Lerond, Jerome" sort="Lerond, Jerome" uniqKey="Lerond J" first="Jerome" last="Lerond">Jerome Lerond</name><name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Véronique" last="Sgambato-Faure">Véronique Sgambato-Faure</name><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name><name sortKey="Tremblay, Leon" sort="Tremblay, Leon" uniqKey="Tremblay L" first="Leon" last="Tremblay">Leon Tremblay</name><name sortKey="Vallet, Anne Evelyne" sort="Vallet, Anne Evelyne" uniqKey="Vallet A" first="Anne-Evelyne" last="Vallet">Anne-Evelyne Vallet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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